Inhibition of Mast Cell Degranulation by Novel Small Molecule MRGPRX2 Antagonists

Mas-related G-protein coupled receptor X2 (MRGPRX2) is a promiscuous receptor on mast cells that mediates IgE-independent degranulation and has been implicated in a number of mast cell-mediated issues, together with persistent urticaria, atopic dermatitis, and ache issues. Though it’s a promising therapeutic goal, few potent, selective, small molecule antagonists have been recognized, and purposeful results of human MRGPRX2 inhibition haven’t been evaluated in vivo.

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