Regulatory T (Treg) cells play an important function in imposing peripheral immune tolerance and selling tissue homeostasis and restore. Our understanding of their pivotal function in immune regulation has critically benefited from the identification of a rising variety of inborn errors of immunity (IEI), collectively often known as Tregopathies, that focus on completely different pathways governing Treg cell biology. The ensuing problems related to mutations in gene akin to FOXP3, CTLA4, IL2RA, IL2RB, BACH2, IKAROS, STAT3, LRBA, and DEF6 manifest each distinctive and overlapping phenotypes of immune dysregulation and autoimmunity, highlighting the distinctive roles of particular person Treg cell pathways focused by IEI in immune regulation.
Trending Merchandise
