Mast cell (MC)-derived mediators induce vasodilatation and fluid extravasation, resulting in cardiovascular failure in extreme anaphylaxis. We’ve beforehand revealed a synergistic interplay between the cytokine IL-4 and the MC-derived mediator histamine in modulating vascular endothelial (VE) dysfunction and extreme anaphylaxis. The mechanism by which IL-4 exacerbates histamine-induced VE dysfunction and extreme anaphylaxis are unknown.
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