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IL-4 acts on skin derived dendritic cells to promote the Th2 response to cutaneous sensitization and the development of allergic skin inflammation

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Atopic dermatitis is characterised by scratching and a Th2-dominated native and systemic response to cutaneously encountered antigens. Dendritic cells (DCs) seize antigens within the pores and skin and quickly migrate to draining lymph nodes (dLNs) the place they drive the differentiation of antigen-specific naïve T cells.

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