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IL-18 in atopic dermatitis – A multifaceted driver of skin inflammation

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Atopic dermatitis (AD) is a standard power inflammatory pores and skin illness characterised by pruritus, barrier dysfunction and immune cell infiltration. Regardless of vital progress in our understanding of AD pathophysiology, the molecular mechanisms driving the illness stay solely partially elucidated. Just lately, the cytokine IL-18, a member of the IL-1 household, has drawn consideration for its involvement in numerous immune responses and potential affect on illness severity. On this evaluate, we look at the function of IL-18 in AD, with a give attention to genetic associations, biomarker potential, and mobile sources.

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