Human angiotensin converting enzyme 2 specific antisense oligonucleotides reduce infection with SARS-CoV-2 variants

The Spike protein mutation of SARS-CoV-2 led to decreased protecting impact of assorted vaccines and monoclonal antibodies, suggesting that blocking SARS-CoV-2 an infection by focusing on host components would make the remedy extra resilient towards virus mutations. Angiotensin changing enzyme 2 (ACE2) is the host receptor of SARS-CoV-2 and its variants, in addition to many different coronaviruses. Down-regulation of ACE2 expression within the respiratory tract could stop viral an infection. Antisense oligonucleotides (ASOs) may be rationally designed primarily based on sequence information, require no supply system, and may be administered regionally.

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