Hidradenitis suppurativa: Why dose escalation often fails and what biology tells us about next steps

Hidradenitis suppurativa (HS) is a power, debilitating, inflammatory pores and skin illness characterised by painful nodules, abscesses, and draining tunnels.1 Regardless of a excessive burden of illness, the therapeutic choices stay restricted: solely 3 focused biologics are presently accepted (ie, adalimumab [anti-TNF], secukinumab [anti–IL-17A], and bimekizumab [anti–IL-17A/F]), and response charges (as measured by 50% enchancment in acute abscess and nodule depend [HiSCR50] rating) typically vary from roughly 45% to 60%.

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