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Heterozygous loss of MAP4K1 causes immune dysregulation by amplifying T cell responses

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CAPSULE SUMMARY: HPK1 deficiency, attributable to heterozygous lack of MAP4K1, is a newly acknowledged monogenic reason for immune dysregulation with incomplete penetrance. HPK1-deficient T cells exhibit heightened activation and inflammatory cytokine manufacturing, implicating HPK1 as a key detrimental regulator of human T cell responses.

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