Granzyme K– and amphiregulin-expressing cytotoxic T cells and activated extrafollicular B cells are potential drivers of IgG4-related disease

IgG4-related illness (IgG4-RD) is a progressive situation that’s characterised by multiorgan irritation, elevated serum IgG4 ranges, tissue infiltration by IgG4+ plasma cells, tertiary lymphoid buildings (tertiary lymphoid organs [TLOs]) with germinal facilities (GCs), and storiform fibrosis in varied organs, together with salivary glands.1-3 Each B and T cells are ample in illness lesions,4-8 and the efficacy of B-cell depletion means that activated B cells are key contributors to illness pathogenesis.

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