Garadacimab For Hereditary Angioedema Prophylaxis In Adolescents: Efficacy And Safety From The Phase 3 (VANGUARD) Study And Open-Label Extension (Second Interim Analysis)

Hereditary angioedema (HAE) assaults are recurrent and unpredictable. In a pivotal Section 3 examine (adults/adolescents), garadacimab (anti-activated issue XII monoclonal antibody) considerably decreased month-to-month assault charge vs placebo (imply: 0.27 vs 2.01, 87% discount; median: 0.00 vs 1.35, 100% discount; P<0.0001) with a positive tolerability/security profile. We report information in adolescents from the pivotal Section 3 examine and open-label extension (OLE, second interim evaluation; NCT04739059).

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