Flow cytometry-based basophil and mast cell activation tests in allergology: state-of-the-art

The main problem in allergy analysis is the event of accessible and dependable diagnostics that may predict the medical end result upon the publicity to offender allergen(s) or cross-reactive molecules and the identification of safer alternate options in comparison with present state-of-the-art strategies. There may be accumulating proof that flow-based analyses for the quantification of activated basophils and mast cells upon in vitro problem (Basophil and Mast Cell Activation Check, or BAT and MAT) might meet the diagnostic necessities for IgE-dependent allergic reactions, drug hypersensitivities and subsets of autoimmune urticaria.

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