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Evaluating hypogammaglobulinemia after CD19 CAR T-cell therapy

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We learn with curiosity the research by Sutherland et al1 exploring the affiliation of CD19-targeted chimeric antigen receptor (CAR) T-cell remedy with hypogammaglobulinemia, an infection, and mortality. This analysis presents an important contribution to understanding immunoglobulin deficiencies following CAR T-cell remedy, offering actionable insights for clinicians managing posttreatment problems in hematologic malignancies.1 Nonetheless, a number of solutions warrant additional dialogue to higher contextualize these findings.

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