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Endotypes of chronic spontaneous urticaria in children

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We learn with nice curiosity the latest evaluation by Wong et al on endotypes of power spontaneous urticaria (CSU).1 The authors present a complete and well timed overview of the immunologic mechanisms underpinning CSU, delineating the diagnostic and therapeutic implications of the kind I (autoallergic) and sort IIb (traditional autoimmune) endotypes. We significantly appreciated their effort to combine these mechanistic insights right into a clinically significant framework.

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