Early-life Upper Airway Microbiota are Associated with Decreased Lower Respiratory Tract Infections

Microbial interactions mediating colonization resistance play key roles throughout the human microbiome, shaping susceptibility to an infection from beginning. To achieve perception into microbiome-mediated defenses and respiratory pathogen colonization dynamics, we sequenced and analyzed nasal (n=229) and oral (n=210) microbiomes with related well being/environmental information from our Wisconsin Toddler Examine Cohort at age 24-months. Contributors with early-life decrease respiratory tract an infection (LRTI) have been extra prone to be formula-fed, attend daycare, and expertise wheezing.

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