Deconstructing inflammatory memory across tissue setpoints using cell circuit motifs

Tissue ecosystems are mobile communities that keep setpoints by means of a community of intercellular interactions. We place well being and power inflammatory illness as various steady setpoints which can be: (1) strong to perturbation, and (2) able to adaptation and reminiscence. Inflammatory reminiscence–the storage of prior expertise to durably affect future responsiveness–is central to how tissue ecosystems could also be pushed previous tipping factors that stabilize illness over well being. Right here, we develop a reductionist framework of circuit motifs that recur in tissue setpoints.

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