CAR-T cell therapy : recent updates and challenges in autoimmune diseases

Chimeric antigen receptor T cell (CAR-T) remedy has revolutionized the therapy of hematological malignancies, demonstrating vital medical efficacy and resulting in FDA approval of a number of CAR-T cell-based merchandise. This success has prompted exploration of CAR-T cell remedy in different illness areas, together with autoimmune ailments (AIDs). CAR-T cells concentrating on B cells have been proven to offer medical and organic enhancements in sufferers with refractory AIDs. The intention of this evaluate is to debate promising methods involving CAR-T cells in AIDs, comparable to these concentrating on B cells and T cells, and to discover new approaches concentrating on fibroblasts or plasmacytoid dendritic cells.

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