We learn with nice curiosity the article by Khoury et al that was printed in a current subject of the Journal of Allergy and Scientific Immunology.1 Episodic angioedema with eosinophilia (EAE [Gleich syndrome]) associated to CD3–CD4+ lymphocytic hypereosinophilic syndrome (L-HES) is a uncommon but often relapsing illness, and Khoury et al must be counseled for performing a potential open-label trial on this setting.1 On this pilot research, regardless of lowering blood absolute eosinophil counts and ranges of each plasma and urine eosinophil granule proteins, high-dose mepolizumab failed to cut back signs of swelling or improve the time between flares in all 5 handled sufferers.
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