Standard therapy choices for sufferers identified with stable cancers or autoimmune ailments are sometimes restricted or ineffective. Creating various therapies for these difficult situations requires analysis to ascertain an in-depth understanding of how the immune system acknowledges, targets, and destroys most cancers cells. Typical immunology workflows contain quite a few assays and hundreds of pipetting steps, which could be laborious and error-prone when carried out manually. The implementation of automated liquid dealing with options – similar to INTEGRA Biosciences’ ASSIST PLUS pipetting robot – helps to optimize protocols and scale back errors, rising effectivity, throughput and screening capability.
INTEGRA’s automated liquid dealing with options and pipetting software program are supporting the seek for novel most cancers therapies at California-based 3T Biosciences, a spin-out from Stanford College that focuses on growing T-cell partaking bispecific antibodies to focus on novel peptide-HLA targets. Its proprietary 3T-TRACE™ platform technology takes benefit of various goal libraries and machine-learning algorithms to determine and validate novel T-cell receptors and targets from affected person immune responses. This permits detection of probably the most prevalent immunogenic targets in stable tumors, which might then be focused therapeutically. The corporate makes use of benchtop automation options from INTEGRA to boost the reproducibility and productiveness of its pipetting workflows, serving to to speed up the event of more practical therapeutics.
3T Biosciences has been utilizing numerous handheld INTEGRA merchandise – together with EVOLVE lightweight manual pipettes, VOYAGER adjustable tip spacing pipettes and a VIAFLO 96 handheld electronic pipette – for a number of years. Nonetheless, as the corporate grew, so did the necessity for automation options to extend effectivity in goal discovery and therapeutic improvement. The crew wished to scale back its reliance on guide pipetting – which is susceptible to errors – and standardize protocols for better accuracy and reproducibility. Due to earlier constructive experiences with INTEGRA units, the laboratory as soon as once more turned to the corporate because it sought a user-friendly answer that may enable its total crew to learn from laboratory automation, creating and modifying protocols in keeping with experimental necessities with out the necessity for automation experience.
Automation for elevated reliability
Equipping INTEGRA’s ASSIST PLUS pipetting robotic with a D-ONE single channel pipetting module proved the right answer for automation of protein distribution, normalization and aliquoting. The compact measurement of the ASSIST PLUS fitted simply inside the laboratory’s biosafety hood – making it ideally suited for cell tradition work – and the platform may be used to automate the crew’s current VOYAGER handheld pipettes.
The implementation of the ASSIST PLUS set-up has led to important workflow enhancements, lowering human errors and offering extra consistency in liquid dealing with. Protocol execution has been standardized, serving to to make sure uniform outcomes throughout completely different customers and experiments, similar to throughout lentiviral manufacturing and transfections. Automation of repetitive duties has additionally lowered the laboratory’s guide workloads, releasing up employees to hold out extra sophisticated and technical processes.
Extra accessible and environment friendly workflows
The laboratory makes use of INTEGRA’s VIALAB pipette automation software to program a various array of protocols on the ASSIST PLUS with out the necessity for in-house automation experience. This easy-to-use software program package deal contains a user-friendly graphical interface, enabling employees with restricted programming expertise to rapidly and simply arrange and run advanced workflows. This helps the crew to realize superior lab automation, enhancing effectivity and scientific outcomes, whereas nonetheless having the flexibleness to satisfy its rising wants and permit different potential functions sooner or later.
Superior options backed by knowledgeable assist and repair
Selecting an automation answer is simply the beginning. INTEGRA’s knowledgeable service crew supplied all the recommendation and assist crucial to make sure seamless and stress-free integration of its automation capabilities into the laboratory’s workflows. From implementation recommendation to utility assist, INTEGRA’s environment friendly and responsive crew was readily available to rapidly direct the laboratory to the best specialists. Trying to the longer term, 3T Biosciences goals to combine automation into extra liquid dealing with processes to extend its excessive throughput screening capability, optimize workflows for extra advanced organic assays, and develop extra standardized protocols for therapeutic discovery.
To study extra about how INTEGRA’s automation options can improve reproducibility and speed up discovery, go to https://www.integra-biosciences.com
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