Airway hyperresponsiveness correlates with airway TSLP in asthma independent of eosinophilic inflammation

Thymic stromal lymphopoietin (TSLP) is launched from the airway epithelium in response to numerous environmental triggers, inducing a type-2 inflammatory response, and is related to airway irritation, airway hyperresponsiveness (AHR), and exacerbations. TSLP might also induce AHR through a direct impact on airway easy muscle and mast cells, independently of type-2 irritation, though affiliation between airway TSLP and AHR throughout bronchial asthma phenotypes has been described sparsely.

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