A molecular basis for milk allergen immune recognition in eosinophilic esophagitis

Because the early Eighties, eosinophilic esophagitis (EoE) has been managed as a scientific meals allergy.1 Nevertheless, immunologic proof of meals antigen recognition by the immune system in sufferers with EoE has solely just lately develop into out there.2-4 Regardless of these advances, a meals antigen–particular T cell has but to be recognized in a affected person with EoE. To handle this information hole, we enrolled a topic with clinically established EoE milk allergy (EoE topic 1) in an institutional evaluate board protocol (18-015524), collected the affected person’s peripheral blood, and stimulated the PBMCs with milk proteins as beforehand described.

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