β1 integrin-mediated mast cell immune-surveillance of blood vessel content

Immunoglobulin E, IgE)-mediated degranulation of mast cells, MCs) supplies speedy safety in opposition to environmental hazards, together with animal venoms. A fraction of tissue-resident MCs intimately associates with blood vessels. These perivascular MCs had been reported to increase projections into the vessel lumen and to be the primary MCs to amass intravenously injected IgE, suggesting that IgE loading of MCs is determined by their vascular affiliation.

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