Autoantibodies against IFN-γ in a subgroup of patients with atopic dermatitis and a history of eczema herpeticum

Sufferers with atopic dermatitis (AD) are liable to cutaneous viral infections, significantly eczema herpeticum (EH), a disseminated herpes simplex virus (HSV) an infection, whose manifestation could trigger encephalitis, pneumonia, and bacterial superinfection.1 Within the TREATgermany registry of grownup sufferers with moderate-to-severe AD, 21.8% of sufferers reported EH, and greater than half skilled recurrent episodes, suggesting an underlying susceptibility.2 Danger elements embody early-onset AD, allergic comorbidities, and recurrent HSV an infection.

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