Mechanistic insights into petechiae observed with remibrutinib therapy in chronic spontaneous urticaria

We learn with curiosity the overview by Lin et al on Bruton tyrosine kinase (BTK) inhibitors (BTKis) for allergic issues, together with continual spontaneous urticaria.1 With the current US Meals and Drug Administration approval of remibrutinib (Rhapsido) as the primary oral BTKi for adults with antihistamine-resistant continual spontaneous urticaria, consideration has turned to its security profile. Within the section 3 REMIX-1 and REMIX-2 trials, remibrutinib produced fast and sturdy symptom management, but petechiae had been reported in 3.8% of sufferers versus in 0.3% of these with commonplace remedy.

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