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Rochman et al (J Clin Make investments 2025;135:e194080; https://doi.org/10.1172/JCI194080) developed a novel therapeutic technique to restrict TH2 cell immunity by administration of allergen-encoding mRNA fused to lipid nanoparticles (mRNA-LNP). Immunization with mRNA-LNPs enhanced TH1 and allergen-specific IgG responses whereas concurrently impairing allergen-specific IgE, TH2, and TH17 cell responses. Moreover, immunopathology was ameliorated in each preventive and established experimental murine fashions of allergic airway irritation.

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