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Immune Functions of the Esophagus

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The esophagus has lengthy been thought to be a easy conduit for meals transport. A brand new paradigm now acknowledges it as an immune organ actively concerned in environmental sensing, antigen tolerance, and neuroimmune signaling to take care of mucosal homeostasis. The stratified squamous epithelium offers a significant bodily barrier, supported by transmembrane mucins and controlled by post-translational modifications, together with citrullination mediated by esophagus-enriched peptidyl arginine deiminases. A singular esophageal microbiome, established early in life, shapes epithelial differentiation, gene expression, and immune growth and response.

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