The diagnostic pitfall of sIL-2R in hemophagocytic lymphohistiocytosis: A key marker lost in analytic translation

Soluble IL-2 receptor (sIL-2R [sCD25]) is a key biomarker in ailments characterised by substantial T-cell activation,1,2 by which it contributes to each, prognosis and prediction of prognosis.3 As an indicator of hemophagocytic lymphohistiocytosis (HLH), an sIL-2R stage larger than 2400 U/mL is included among the many 7 HLH-2004 standards.4,5 The optimized HLH inflammatory index (OHI), outlined as an sIL-2R stage larger than 3900 U/mL and ferritin stage larger than 1000 ng/mL, performs a vital function within the prognosis and prognosis of malignancy-associated HLH.

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