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Identification of disease-specific regulatory networks in Prurigo Nodularis vs. Atopic Dermatitis through ATAC/RNA single-nuclei profiling
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This examine identifies distinct epigenomic regulatory mechanisms in Prurigo Nodularis, highlights AP-1-induced RUNX2 expression in fibrosis, and demonstrates nemolizumab’s potential in reversing disease-specific dysregulation, advancing therapeutic methods for clinicians.
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