Asthma programs the transcriptional response of human nasal epithelial cells to SARS-CoV-2 Spike–mediated ACE2 engagement

Extreme acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the agent liable for the coronavirus illness 2019 (COVID-19) pandemic, infects a number of tissues and organs and stays prevalent within the normal inhabitants. People with respiratory comorbidities have been reported to be at larger threat for extreme an infection and deadly outcomes,1 however the results of atopy and bronchial asthma on the susceptibility to, and extra usually, the biology of SARS-CoV-2 an infection are incompletely understood.

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