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CARMIL2 deficiency disrupts activation-induced metabolic reprogramming in T cells, and is partially rescued by glutamine supplementation

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CARMIL2-mutated CD4+ T cells current impaired immune activation, diminished NF-κB and mTOR signaling and altered metabolic reprogramming, partially restored by glutamine supplementation. Focusing on T cell metabolism may supply new therapeutic approaches for sufferers with IEI.

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