We’ve got a new systems vaccinology paper out at npj Vaccines!
The examine tackles the problematic query of why transplant sufferers responded so poorly to the COVID vaccine. Whereas most individuals had nice antibodies from a single dose, solely half of transplant sufferers have responded even after three!
We took blood from 20 wholesome, 31 lung transplant and 59 kidney transplant sufferers previous to vaccination, and profiled 444 immunological parameters, to get a complete programs immunology profile. We then adopted who did and did not reply to the vaccine, to seek out the immunological associates.
First up, there are scientific results: Vaccine response was particularly poor quickly after transplantation, and in sufferers on immunosuppressive cocktails, particularly these together with MMF. Even taking this under consideration, there have been immunological drivers related to poor response.
As you may predict, the sufferers that responded finest have been these with an immune profile that had returned nearer to regular post-transplantation. In actual fact, you possibly can predict vaccine response with 93% accuracy simply based mostly on 10 immune parameters.
Oddly although, some sufferers have been in a position to hobble collectively a poor however detectable response after two pictures. These sufferers did not have a extra regular immune profile, and had fairly uncommon relationships between immune populations, suggesting that that they had put collectively a poor-but-functional “kludge”.
This examine was a joint initiative from our lab, Arnaud Marchant’s lab at at ULB and Stephanie Humblet-Baron’s lab at KU Leuven.
Large because of all workforce members, particularly Nicolas Gemander, Julika Neumann, Rafael Veiga and Isabelle Etienne for his or her management roles.
Greatest thanks of all to the sufferers who volunteered for the examine!
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