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Though a number of biologic therapies that concentrate on kind 2 irritation can be found for remedy of persistent rhinosinusitis with nasal polyps (CRSwNP), all of them require dosing each few weeks. Gevaert et al (Lancet 2025;405(10482):911-26; https://doi.org/10.1016/S0140-6736(25)00197-7) carried out 2 randomized, placebo-controlled trials (ANCHOR-1 and ANCHOR-2) involving over 500 topics mixed to evaluate the protection and efficacy of depemokimab, an ultra-long-acting anti-IL-5 biologic, in adults with CRSwNP.

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