Lessons from the clinical use of ex vivo T-lymphopoiesis assays

Congenital athymia is a uncommon dysfunction related to life-limiting T-lymphocytopenia. More and more, sufferers with athymia are recognized by new child screening for extreme mixed immunodeficiency and T-lymphocytopenia, selling early therapy with thymus transplantation. Regardless of entry to fast turnaround scientific genetic testing, a major proportion of infants with selective T-lymphocytopenia lack a molecular prognosis. Latest scientific pointers by the European Society for Immunodeficiencies suggest utilizing ex vivo T-lymphopoiesis assays to help in scientific resolution making between hematopoietic cell transplantation (HCT) and thymus transplantation in genetically undefined T-lymphocytopenia.

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