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CAR therapies: development, design, and implementation

Chimeric antigen receptor (CAR) T and NK cell therapies characterize a promising technique for the therapy of cancers and different power illnesses. Engineered CAR constructs endow immune cells with the power to focus on desired antigens with excessive specificity, permitting for directed responses to antigen-expressing cells. CAR T and NK cells have proven marked success within the therapy of hematological malignancies, though there stays a big inhabitants of sufferers that fail to answer CAR therapies and their efficacy in stable tumors continues to be restricted.

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