Update on inborn errors of immunity

Ever for the reason that first description of an inherited immunodeficiency in 1952 in a boy with gammaglobulin deficiency, new insights have progressed quickly in problems that at the moment are known as inborn errors of immunity (IEI). In a subject the place basic molecular biology, genetics, immune signaling and scientific care are tightly intertwined, 2022-2024 noticed a large number of advances. Right here we report a collection of analysis updates with a major concentrate on (1) analysis and screening, (2) new genetic defects, (3) susceptibility to extreme COVID-19 an infection and affect of vaccination, and (4) remedy.

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