Eosinophilic Esophagitis Drives Tissue Fibroblast Regenerative Programs Towards Pathologic Dysfunction

Pathologic tissue reworking with scarring and tissue rigidity has been demonstrated in inflammatory, autoimmune, and allergic illnesses. Eosinophilic esophagitis (EoE) is an allergic illness that’s recognized and managed by repeated biopsy procurement, permitting an understanding of tissue fibroblast dysfunction. Whereas EoE related tissue reworking causes scientific dysphagia, meals impactions and esophageal rigidity and strictures, molecular mechanisms driving these issues stay underneath investigation.

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