Important molecular differences between therapeutic IL-6 receptor inhibition and its genetic mimicry in patients with AD

We learn with curiosity the latest report by Zhao and Yiu describing an affiliation between inhibition of the IL-6 receptor (IL-6R) and the chance of atopic dermatitis (AD).1 For this, Zhao and Yiu1 used genetic knowledge from 343,524 people relating to single-nucleotide polymorphisms (SNPs) which can be positioned inside or close to the IL6R gene (which encodes the IL-6R) and had been related to serum ranges of C-reactive protein (CRP). Zhao and Yiu1 declare that this strategy is ready to genetically mimic IL-6R inhibition by mAbs akin to tocilizumab (TCZ).

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