Lignans are plant-based compounds that, as soon as ingested, are transformed into enterolignans by intestine micro organism. These enterolignans, significantly enterolactone, are believed to have protecting results in opposition to numerous persistent illnesses, together with Kind 2 Diabetes (T2D). A research revealed in Journal of the American Medical Association investigates the affiliation between lignan consumption and the chance of kind 2 diabetes (T2D), using knowledge from a number of giant cohorts, together with the Nurses’ Well being Examine (NHS), NHSII, and the Well being Professionals Observe-up Examine (HPFS).
The research utilized a sturdy methodology to evaluate the affect of lignan consumption on T2D danger and associated biomarkers. Fasting blood samples had been collected from members, and plasma enterolactone concentrations had been measured utilizing superior liquid chromatography mass spectrometry. Dietary lignan consumption was assessed by means of meals frequency questionnaires, and members’ diets had been monitored over a number of years. The research additionally managed for a wide range of potential confounders, together with physique mass index (BMI), bodily exercise, smoking habits, alcohol consumption, and household historical past of diabetes.
The research discovered a major inverse affiliation between lignan consumption and T2D danger. Individuals with greater lignan consumption exhibited an 8% to 27% decrease danger of creating T2D, relying on the precise lignan compound. Secoisolariciresinol, one of many particular person lignans, confirmed the strongest protecting impact, particularly amongst members with a BMI of 30 or greater and amongst premenopausal ladies. The research additionally examined the connection between lignan consumption and HbA1c ranges, a key biomarker for long-term blood glucose management. Greater lignan consumption was related to decrease HbA1c ranges, suggesting that lignans could assist enhance glycemic management.
Total, this research supplies sturdy proof that greater lignan consumption is related to a decrease danger of T2D and higher glycemic management. These findings have vital implications for dietary suggestions, suggesting that growing lignan-rich meals, corresponding to flaxseeds, entire grains, and greens, may very well be a helpful technique for stopping T2D.
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