Panallergens are sometimes the most important reason behind allergic signs, however they are often related to a number of sensitizations and comorbidities resembling pollen-food allergy syndrome or bronchial asthma. Furthermore, panallergens intervene with the diagnostic identification of the offender allergen, thus hampering exact prescription of allergen immunotherapy in polysensitized sufferers. Profilins and polcalcins are well-known panallergens extensively utilized in in vitro diagnostics of pollen allergy. Nonetheless, they didn’t clarify why Italian youngsters with seasonal allergic rhinitis in a earlier cohort examine reacted to allergen extracts of birch and different pollen even within the absence of sensitization to Guess v 1 or different respective main allergic molecules.
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