Exploring the skin microbiome in atopic dermatitis pathogenesis and disease modification

Inflammatory pores and skin ailments, like atopic eczema (atopic dermatitis, AD), have an effect on kids and adults globally. In AD, the pores and skin barrier is impaired on a number of ranges. Underlying components embody genetic, chemical, immunological, and microbial parts. Elevated pores and skin pH in AD is a part of the altered microbial microenvironment that promotes overgrowth of the pores and skin microbiome with Staphylococcus aureus (S. aureus). The secretion of virulence components, like toxins and proteases, by S. aureus additional aggravates the pores and skin barrier deficiency and moreover off-balances the already skewed immune response.

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