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Loss of the TRPM4 channel in humans causes immune dysregulation with defective monocyte migration

Transient receptor potential melastatin subfamily member 4 (TRPM4) is a broadly expressed, calcium-activated, monovalent cation channel that regulates immune cell operate in mice and cell strains. Clinically nonetheless, partial loss or achieve of operate mutations in TRPM4 result in arrythmia and coronary heart illness, with no documentation of immunological problems.

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