Neuroimmune interplay during type 2 inflammation: Symptoms, mechanisms, and therapeutic targets in atopic diseases

Kind 2 irritation is characterised by overexpression and heightened exercise of kind 2 cytokines, mediators, and cells that drive neuroimmune activation and sensitization to beforehand subthreshold stimuli. The results of altered neuroimmune exercise differ by tissue kind and illness; they embrace pores and skin irritation, sensitization to pruritogens, and itch amplification in atopic dermatitis and prurigo nodularis; airway irritation and/or hyperresponsiveness, lack of expiratory quantity, airflow obstruction and elevated mucus manufacturing in bronchial asthma; lack of sense of odor in continual rhinosinusitis with nasal polyps; and dysphagia in eosinophilic esophagitis.

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