Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complicated 2 (NOX2) deficiency, also referred to as persistent granulomatous illness (CGD),1 is a uncommon inborn error of immunity that abolishes the perform of the phagocytic NADPH oxidase complicated 2, which is the principle supply of reactive oxygen species (ROS) manufacturing in phagocytic cells. NOX2 deficiency is attributable to loss-of-function mutations within the gene encoding the subunits of the NOX2 complicated. The membrane-bound cytochrome b558, a heterodimer of gp91phox and p22phox subunits, constitutes the catalytic subunit of the NOX2 complicated and associates, on cell activation, with 4 different cytosolic proteins (p47phox, p67phox, p40phox, and a GTPase Rac).
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