Your Path to Vitality through a Curated Selection of Nature's Best for Immune Health and Joint Comfort

NOX2 deficiency enhances priming and activation of the NLRP3 inflammasome

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complicated 2 (NOX2) deficiency, also referred to as persistent granulomatous illness (CGD),1 is a uncommon inborn error of immunity that abolishes the perform of the phagocytic NADPH oxidase complicated 2, which is the principle supply of reactive oxygen species (ROS) manufacturing in phagocytic cells. NOX2 deficiency is attributable to loss-of-function mutations within the gene encoding the subunits of the NOX2 complicated. The membrane-bound cytochrome b558, a heterodimer of gp91phox and p22phox subunits, constitutes the catalytic subunit of the NOX2 complicated and associates, on cell activation, with 4 different cytosolic proteins (p47phox, p67phox, p40phox, and a GTPase Rac).

Trending Merchandise

0
Add to compare
healthycell-ac-11-supplement-supports-cell-dna-repair-from-cats-claw-anti-aging-stem-cell-health-immune-boost-30-capsules
0
Add to compare
$32.99
0
Add to compare
cats-claw-tincture-organic-cats-claw-herb-drops-uncaria-tomentosa-bark-liquid-extract-alcohol-free-vegan-supplement-2-fl-oz
0
Add to compare
$13.99
0
Add to compare
cats-claw-tincture-organic-cats-claw-herbal-supplement-uncaria-tomentosa-bark-liquid-extract-cats-claw-herb-drops-vegan-alcohol-free-4-fl-oz
0
Add to compare
$17.99
0
Add to compare
cats-claw-tincture-2-fl-oz-cats-claw-extract-for-joint-support-immune-support-supplement-organic-cats-claw-liquid-drops-uncaria-tomentosa
0
Add to compare
$7.85
0
Add to compare
pure-encapsulations-cats-claw-supplement-to-support-joints-immune-and-cardiovascular-systems-and-gastrointestinal-health-90-capsules
0
Add to compare
$45.40
0
Add to compare
cats-claw-herb-extract-tincture-2-fl-oz-alcohol-free-vegetarian-non-gmo-gluten-free-liquid-by-horbaach
0
Add to compare
$9.99
0
Add to compare
carlyle-cats-claw-capsules-1000mg-180-count-uncaria-tomentosa-non-gmo-gluten-free-supplement
0
Add to compare
$15.28
.

We will be happy to hear your thoughts

Leave a reply

CatsClaw
Logo
Register New Account
Compare items
  • Total (0)
Compare
0
Shopping cart