Mast Cell-Sensory Neuron Crosstalk in Allergic Diseases

Mast cells (MCs) are tissue-resident immune cells, well-positioned on the host-environment interface for detecting exterior antigens and taking part in a important function in mobilizing innate and adaptive immune responses. Sensory neurons are afferent neurons innervating most areas of the physique however particularly within the periphery, the place they sense exterior and inner alerts and relay info to the mind. The importance of MC-sensory neuron communication is now more and more turning into acknowledged, particularly as each cell sorts are in shut bodily proximity on the host-environment interface and round main organs of the physique and produce particular mediators that may activate one another.

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