Resident memory T cells in nonlesional skin and healed lesions of patients with chronic inflammatory diseases: Appearances can be deceptive

Tissue-resident reminiscence T (TRM) cells function a primary line of protection in peripheral tissues to guard the organism in opposition to overseas pathogens. Nonetheless, autoreactive TRM cells are more and more implicated in autoimmunity, as evidenced in continual autoimmune and inflammatory pores and skin situations. This highlights the necessity to characterize their phenotype and perceive their position for the aim of concentrating on them particularly with out affecting native immunity. Up to now, the investigation of TRM cells in human pores and skin illnesses has targeted primarily on lesional tissues of sufferers.

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