TRPV1-positive sensory nerves and neuropeptides are involved in epidermal barrier repair after tape stripping in mice

The integumentary system serves as a proficient barrier, and the outermost layer of the pores and skin dermis, known as the stratum corneum, contains terminally differentiated keratinocytes that produce filaggrin (FLG) (encoded by the gene Flg), which is without doubt one of the key parts within the stratum corneum barrier. Though the significance of sensory nerves within the wound therapeutic course of has been urged,1 their particular function in restoration of the pores and skin barrier perform stays inadequately understood.

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