Vernix caseosa reveals mechanistic clues linking maternal obesity to atopic dermatitis pathogenesis

Atopic dermatitis (AD) is a power inflammatory pores and skin situation with a fancy pathogenesis that mixes genetic and environmental elements.1 AD pores and skin is characterised by barrier dysfunction, altered immune responses, and bacterial dysbiosis, resulting in itchy eczematous lesions with recurrent flare-ups.2,3 Maternal obese and weight problems have been linked to elevated AD danger within the offspring;4,5 nevertheless, the precise relationship between these situations stays unclear. Maternal weight extra could alter immune homeostasis, rising the pores and skin’s susceptibility to irritation.

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