Precision engineering for localization, validation and modification of allergenic epitopes

The allergen-IgE interplay is important for the genesis of allergic responses, but investigation of the molecular foundation of those interactions is in its infancy. Precision engineering has unveiled the molecular options of allergen-antibody interactions on the atomic degree. Excessive decision applied sciences, together with X-ray crystallography, nuclear magnetic resonance spectroscopy, and cryo-electron microscopy decide allergen-antibody constructions. X-ray crystallography of an allergen-antibody advanced localizes intimately amino acid residues and interactions that outline the epitope-paratope interface.

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