Dysregulated germinal centre reaction with expanded T follicular helper cells in APECED lymph nodes

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED, additionally referred to as APS-1) is an inborn error of immunity with clear indicators of B cell autoimmunity corresponding to neutralising anti-IFN antibodies. In APECED, mutations within the AIRE gene impair thymic adverse number of T cells. The ensuing T cell alterations could then trigger dysregulation of B cells responses. Nonetheless, no evaluation of interactions of T and B cells within the germinal centres in sufferers’ secondary lymphatic tissues has been reported.

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